ProBiota HistaminX is a histamine-friendly probiotic. Unlike most probiotics, it has been meticulously formulated to exclude species of bacteria known to produce histamine. It is a great option for those struggling with histamine intolerance or looking for a probiotic that avoids producing excess histamine in the gut. ProBiota HistaminX is a probiotic supplement for people with histamine intolerance. It supports the gut microbiome but excludes the probiotic strains that can contribute to raised histamine levels. This Ther-Biotic Factor 1 Lactobacillus rhamnosus probiotic can be a good place to start. It’s both a low histamine probiotic and a histamine lowering probiotic. Lactobacillus Combo

Later, you’ll read about some of the probiotics to avoid if you have Mast Cell Activation Syndrome, Histamine Intolerance, or SIBO (Small Intestinal Bacterial Overgrowth).

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BioSpora™ is a powerful, hypoallergenic blend of genetically certified Bacillus coagulans and B. subtilis species formulated to provide unique probiotic support of healthy gastrointestinal and immune function.† Spore-forming bacilli have often been referred to as soil-based microorganisms because of their ubiquitous presence in the earth. When isolated from the human GI tract, spore-forming bacilli have long been thought to be transient bacteria. However, current research shows that Bacillus species are present in the GI tract in numbers higher than can be explained by ingestion alone. Germination of Bacillus spores within the human small intestine and transient colonization is now thought to be part of the normal life cycle of human-associated Bacillus species providing specific stimuli for healthy GI and immune system development and function. Each capsule of BioSpora™ supplies a total of 2 billion CFUs of B. coagulans and B. subtilis spores positively identified through independent 16S ribosomal RNA gene sequencing. The spores are resistant to extremes of heat, ultraviolet radiation, solvents, hydrogen peroxide, and enzymes. The spores withstand stomach acid and germinate in the small intestine within 6 hours of ingestion. Ingested B. coagulans and B. subtilis reside in the human GI tract for up to 7 days following consumption. BioSpora™ is recommended for enhanced support of normal GI and immune function.† It is certified free of casein, gluten, and soy. BioSpora™ does not require refrigeration. Histamine is metabolized in your body via your DAO (diamine oxidase) enzymes. Due to genetic variations, some individuals have slower DAO enzymes. Your DAO enzymes can also become stressed from your environment or lifestyle. This can slow down histamine metabolism, leading to high histamine levels. DAO enzymes can be further slowed by leaky gut, alcohol, and certain drugs. Slow enzyme activity combined with high-histamine foods can cause high histamine levels in your body. This, in turn, can lead to increased levels of inflammation and histamine intolerance in a vicious cycle. Deepika Priyadarshani, W. M., & Rakshit, S. K. (2011). Screening selected strains of probiotic lactic acid bacteria for their ability to produce biogenic amines (histamine and tyramine). International Journal of Food Science &Amp; Technology, 46(10), 2062–2069. https://doi.org/10.1111/j.1365-2621.2011.02717.x Yue, Y., et al. (2020). Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment. Biomedicine &Amp; Pharmacotherapy, 127, 110159. https://doi.org/10.1016/j.biopha.2020.110159 There are a lot of probiotics out there! Some could raise histamine, and some are histamine lowering probiotics.

Bifidobacterium infantis, Bifidobacterium bifidum, Bifidobacterium longum, Lactobacillus salivarius, Lactobacillus plantarum, Bifidobacterium lactis, Bifidobacterium breve.Moon, J. S., Kim, S. Y., Cho, K. J., Yang, S. J., Yoon, G. M., Eom, H. J., & Han, N. S. (2013). Isolation and characterization of histamine-producing bacteria from fermented fish products. Journal of microbiology (Seoul, Korea), 51(6), 881–885. https://doi.org/10.1007/s12275-013-3333-0

In the intestines, these good bacteria will help balance any bad bacteria that may lead to problems like SIBO (Small Intestinal Bacterial Overgrowtth.) Keep reading to learn clear information about probiotics for Histamine Intolerance and Mast Cell Activation Syndrome (MCAS). It will be easier to pinpoint what you are reacting to if you start with just one thing at a time. This includes starting with one probiotic species at a time. Jang, S. E., Trinh, H. T., Chung, Y. H., Han, M. J., & Kim, D. H. (2011). Inhibitory effect of Lactobacillus plantarum K-1 on passive cutaneous anaphylaxis reaction and scratching behavior in mice. Archives of pharmacal research, 34(12), 2117–2123. https://doi.org/10.1007/s12272-011-1215-8 You are saving my life and my hope. And I see you doing the same for many more lost souls around here!Any of those ingredients listed above may cause a reaction if you are dealing with Mast Cell Activation Syndrome or Histamine Intolerance.

Next, read about low histamine probiotics and histamine-lowering probiotic supplements that you can consider. Low Histamine Probiotic Supplements for those with Mast Cell Activation Syndrome or Histamine Intolerance So, should you start probiotics with sprinkles if it means taking it out of the delayed-release capsule?The answer is yes.

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Hawrelak, J. A. (n.d.) Specialist Gastrointestinal Tools: Probiotics. UWS Master of Science in Nutrition and Functional Medicine: Gastrointestinal Imbalances course. If you aren’t as sensitive, you might even be able to start with a probiotic blend that has several species of the same genus. I see a lot of people with Histamine Intolerance, including myself, support themselves by taking the histamine degrading enzyme, DAO (diamine oxidase). Glucoraphanin is a compound found in plants in the genus Brassica (e.g. broccoli and cauliflower). It is thought to support healthy detoxification processes, a strong immune system, and provide mitochondrial support. †